Revolutionizing NGS library preparation through AI-driven digital microfluidic automation.
Miroculus, now part of Integra LifeSciences, represents the cutting edge of lab automation through its Miro Canvas platform. The system utilizes Digital Microfluidics (DMF) technology, which manipulates discrete droplets of fluids using electrical signals on a chip, eliminating the need for traditional robotic pipetting arms for internal processing. By 2026, the Miroculus architecture has become a staple in decentralized clinical genomics, providing a 'walk-away' solution for complex Next-Generation Sequencing (NGS) library preparation. The platform integrates machine learning algorithms to optimize protocol execution, ensuring high-fidelity reagent mixing and thermal cycling precision. Its technical architecture allows for the automation of protocols from Illumina, Oxford Nanopore, and Pacific Biosciences. Unlike traditional automation, Miroculus focuses on minimizing reagent dead volume and reducing human error through a closed-system design. The platform is positioned as a critical bridge between raw sample acquisition and high-throughput sequencing, offering a scalable solution for labs that require high reproducibility without the footprint of massive liquid handling workstations. Its software ecosystem allows for cloud-based monitoring and protocol sharing, standardizing genomic workflows across global research networks.
Uses Electrowetting-on-Dielectric (EWOD) to move, mix, and split micro-liter droplets on a specialized electrode grid.
Verified feedback from the global deployment network.
Post queries, share implementation strategies, and help other users.
On-chip thermal control allows for PCR amplification and incubation directly within the microfluidic path.
Automated magnetic field application for bead-based cleanups and size selection.
Centralized repository of validated protocols from major sequencing providers.
Optimized fluidic paths designed to handle sample inputs as low as 1ng of DNA.
AI-vision system monitors droplet position and volume in real-time.
Bi-directional data flow between Miro Canvas and Lab Information Management Systems.
Manual library prep for tumor biopsies is prone to human error and low yield.
Registry Updated:2/7/2026
Sequence on Illumina NovaSeq
Need for decentralized, rapid sequencing in remote field clinics.
High-volume plant tissue processing with limited lab personnel.