Limbix (by BigHealth)
Evidence-based digital therapeutics for adolescent mental health and behavioral activation.

Revolutionizing epilepsy diagnosis with computational biomarkers and AI-driven EEG analysis.
Neuronostics is a clinical-stage medical technology company that provides a sophisticated digital biomarker platform, BioEP, designed to enhance the speed and accuracy of epilepsy diagnosis. By 2026, Neuronostics has solidified its position as a critical layer in neurology departments, utilizing advanced mathematical modeling of brain activity to simulate seizure susceptibility from standard EEG recordings. Unlike traditional methods that rely on capturing a physical seizure event, the Neuronostics architecture analyzes inter-ictal (between-seizure) data to identify hidden signatures of hyperexcitability. This technical approach addresses the high rate of misdiagnosis in epilepsy (estimated at 20-30%) and significantly reduces the time to treatment. The platform is built on a secure, cloud-native infrastructure that integrates with hospital PACS and Electronic Health Records (EHR) using FHIR/HL7 standards, enabling neurologists to generate objective seizure-risk scores. As a Lead AI Solutions Architect would note, the system's competitive advantage lies in its proprietary dynamical systems theory application, which treats the brain as a complex system rather than relying purely on heuristic-based pattern matching common in standard machine learning models.
A proprietary mathematical model that quantifies how close the brain's network is to a seizure transition point using inter-ictal data.
Evidence-based digital therapeutics for adolescent mental health and behavioral activation.
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Simulates brain activity by applying perturbations to the digital representation of the patient's neural networks.
Advanced signal processing algorithms that filter out muscle movement, eye blinks, and electrical noise automatically.
Stores and compares multiple BioEP scores over time for a single patient to monitor medication efficacy.
Utilizes distributed GPU computing to process high-resolution EEG data in minutes.
Automatically remaps diverse hospital electrode configurations to a standardized computational grid.
Provides visual heatmaps of the brain regions contributing most to the seizure-susceptibility score.
Patients often wait years for a definitive epilepsy diagnosis because standard EEGs often return 'normal' between seizures.
Registry Updated:2/7/2026
Early treatment is initiated.
Trial-and-error approach to medication is slow and can have severe side effects.
EEG recordings in children are notoriously difficult and often short, missing seizure events.