NiftyNet

NiftyNet is an open-source convolutional neural network platform designed specifically for the medical imaging community. Built on top of TensorFlow, it provides a modular and reconfigurable architecture for tasks such as segmentation, regression, classification, and generative adversarial networks (GANs). In the 2026 market landscape, NiftyNet holds a position as a critical legacy framework and a specialized research tool for image-guided therapy. It excels at handling high-dimensional medical data, including 3D and 4D volumes in formats like NIfTI and DICOM. The framework's architecture is built around a 'high-level wrapper' philosophy, allowing researchers to implement complex neural network pipelines through configuration files rather than extensive boilerplate code. While newer frameworks have emerged, NiftyNet's specific focus on clinical workflows and its extensive 'Model Zoo'—which includes pre-trained models for brain, organ, and lesion segmentation—make it a staple for institutional research. Its technical core supports multi-GPU distribution, window-based sampling for large volumetric scans, and a comprehensive suite of medical-specific evaluation metrics like the Dice coefficient and Hausdorff distance.