Kallyope
Deciphering the gut-brain axis through AI-driven drug discovery for transformative therapeutics.

The gold standard for biological pathway mapping and genomic functional annotation.
The Kyoto Encyclopedia of Genes and Genomes (KEGG) is a fundamental database resource used globally to integrate genomic, chemical, and systemic functional information. Its architecture is built upon the mapping of molecular-level datasets, generated by high-throughput sequencing, to higher-order functions of the cell and the organism. In the 2026 landscape, KEGG remains the authoritative benchmark for metabolic pathway reconstruction and orthology-based functional annotation. It operates through a multi-layered database structure: KEGG PATHWAY (system functions), KEGG BRITE (hierarchical classifications), KEGG MODULE (functional units), and KEGG ORTHOLOGY (molecular building blocks). For AI Solutions Architects, KEGG provides the essential ground-truth data required for training predictive biological models, enabling everything from metabolic engineering to personalized medicine. While individual web access remains available for academic researchers, large-scale data ingestion and commercial utilization require a specialized licensing model managed through Pathway Solutions, ensuring data integrity and sustainable curation of biological knowledge.
A manually curated classification of functional orthologs that bridges the gap between genomic information and pathway maps.
Deciphering the gut-brain axis through AI-driven drug discovery for transformative therapeutics.
Accelerating drug discovery through an end-to-end generative AI pipeline for target identification, molecular design, and clinical trial prediction.
The industry-standard interactive visualization tool for integrated exploration of large-scale genomic datasets.
Unlocking the causal biology of disease through Gemini Digital Twins.
Verified feedback from the global deployment network.
Post queries, share implementation strategies, and help other users.
A collection of tools to map molecular objects (genes, proteins, compounds) onto KEGG pathway maps and BRITE hierarchies.
High-speed sequence annotation servers using HMM-based profile matching against the KEGG GENES database.
An integrated information resource of diseases, drugs, and environmental factors linked to genomic information.
Programmatic interface allowing for fine-grained retrieval of entries, search queries, and cross-database linking.
A broad-scale metabolic map view allowing for global visualization of metabolic potential in metagenomes.
Specialized pathways detailing the molecular interactions between human hosts and viral/bacterial pathogens.
Identifying the metabolic capabilities of an uncharacterized microorganism from its genome sequence.
Registry Updated:2/7/2026
Identifying which cellular signaling pathways are upregulated in a specific tumor type.
Identifying potential new uses for existing drugs based on shared target pathways.